Single-span and multi-span describe how a building is supported across its width. They do not, by themselves, identify the member type, connection rigidity, or lateral-force-resisting system.
A single-span building has no intermediate column line between its exterior supports. A multi-span building divides the total width into two or more spans using interior supports.
This decision affects clear floor space, rafter or truss demand, column reactions, foundations, drainage, cranes, expansion planning, and total cost. It should be made from operational requirements before structural optimization begins.