Clear span, eaves height, frame spacing, roof shape, and building length affect member sizes and the number of pieces. A wider clear span can require heavier or deeper members; adding internal columns may reduce frame weight but change the usable layout and foundations. Increasing frame spacing may reduce the number of frames while increasing purlin, girt, and frame demands. There is no universal cheapest grid.
Wind, snow, seismic actions, roof equipment, mezzanines, and cranes can change members, bracing, connections, and foundations. Higher design actions do not increase every cost line in a fixed proportion. The applicable site conditions and required performance must be defined before the frame can be meaningfully priced. ASCE/SEI 7-22 is one example of an action standard used under an adopted US code; other jurisdictions use their applicable rules. See steel structure design standards for the responsibilities of different code systems.
Portal frames, trusses, and multi-span arrangements may all be feasible for a given brief. Their cost differs through steel weight, piece count, connection work, lifting, and usable space. A crane runway or mezzanine should be treated as a defined design input, not as a minor accessory added after a base frame price is set.